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Article

Development of therapeutic approaches to 'triple negative' phenotype breast cancer.

Expert opinion on therapeutic targets - 1 Sept 2008

Shiu Kai-Keen, Tan David S P, Reis-Filho Jorge S

Abstract excerpt

BACKGROUND: Triple negative phenotype (TNP) breast cancers are characterised by the lack of expression of oestrogen and progesterone receptors and of human EGF receptor 2 (HER2) overexpression/amplification. This subgroup of cancers has an aggressive clinical behaviour and is associated with poorer overall survival compared with other subtypes. Given the lack of targets for current tailored therapies in TNP...

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Identifiers

PMID: 18694379
DOI: 10.1517/14728222.12.9.1123

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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