Article
New targets for triple-negative breast cancer.
Oncology (Williston Park, N.Y.) - 1 Sept 2013
Herold Christina I, Anders Carey K
Abstract excerpt
Triple-negative breast cancer (TNBC) lacks the three most commonly targeted receptors in human breast cancer--the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2)/neu--and it is associated with an aggressive natural history. More recently, TNBC has been further dissected into smaller, distinct subsets with unique molecular alterations and response to therapy....
Topics
- Animals
- Antineoplastic Agents
- Drug Design
- Female
- Genetic Predisposition to Disease
- Genomics
- Humans
- Molecular Targeted Therapy
- Phenotype
- Prognosis
- Signal Transduction
- Translational Research, Biomedical