Altered gene expression in highly purified enterocytes from patients with active coeliac disease

doi:10.1186/1471-2164-9-377

Article

Altered gene expression in highly purified enterocytes from patients with active coeliac disease

8 Aug 2008

Abstract excerpt

BACKGROUND: Coeliac disease is a multifactorial inflammatory disorder of the intestine caused by ingestion of gluten in genetically susceptible individuals. Genes within the HLA-DQ locus are considered to contribute some 40% of the genetic influence on this disease. However, information on other disease causing genes is sparse. Since enterocytes are considered to play a central role in coeliac pathology, the aim...

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