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Article

The activity of the spinal muscular atrophy protein is regulated during development and cellular differentiation

19 Oct 2005

Abstract excerpt

Spinal muscular atrophy (SMA) is a lethal neuromuscular disease caused by reduced levels of expression of the survival motor neuron (SMN) protein. SMN is part of a macromolecular complex essential for the assembly of the small nuclear ribonucleoproteins (snRNPs) that carry out pre-mRNA splicing. Although the SMN complex has the potential to control the pathway of snRNP biogenesis, it is not known whether SMN...

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PMID: 16236758
DOI: 10.1093/hmg/ddi390

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