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Article

Targeting of SMN to Cajal bodies is mediated by self-association.

Human molecular genetics - 1 Oct 2007

Morse Robert, Shaw Debra J, Todd Adrian G, Young Philip J

Abstract excerpt

The childhood autosomal recessive disorder spinal muscular atrophy (SMA) is caused by mutations in the survival motor neuron (SMN) gene. SMN localizes diffusely in the cytoplasm and in distinct nuclear structures called Cajal bodies. Cajal bodies are believed to be the storage and processing site...

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Source

Identifiers

PMID: 17635841
DOI: 10.1093/hmg/ddm192

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17635841-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Targeting of SMN to Cajal bodies is mediated by self-association.PMID 17635841Read ↗

Mutations in the survival motor neuron (SMN) protein alter the dynamic nature of nuclear bodies.Semantic proximity Read ↗

Distinct domains of the spinal muscular atrophy protein SMN are required for targeting to Cajal bodies in mammalian cells.Semantic proximity Read ↗

SMN oligomerization defect correlates with spinal muscular atrophy severity.Semantic proximity Read ↗

The exon 2b region of the spinal muscular atrophy protein, SMN, is involved in self-association and SIP1 bindingSemantic proximity Read ↗

A novel human-specific splice isoform alters the critical C-terminus of Survival Motor Neuron proteinSemantic proximity Read ↗

SMA-causing missense mutations in survival motor neuron (Smn) display a wide range of phenotypes when modeled in Drosophila.Semantic proximity Read ↗

RNA-sequencing of a mouse-model of spinal muscular atrophy reveals tissue-wide changes in splicing of U12-dependent intronsSemantic proximity Read ↗

The survival motor neuron protein in spinal muscular atrophySemantic proximity Read ↗

Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteinsSemantic proximity Read ↗

Gemin proteins are required for efficient assembly of Sm-class ribonucleoproteinsSemantic proximity Read ↗

Specific interaction of Smn, the spinal muscular atrophy determining gene product, with hnRNP-R and gry-rbp/hnRNP-Q: a role for Smn in RNA processing in motor axons?Semantic proximity Read ↗

Targeting SR Proteins Improves SMN Expression in Spinal Muscular Atrophy CellsSemantic proximity Read ↗

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