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Article

Targeting of SMN to Cajal bodies is mediated by self-association.

Human molecular genetics - 1 Oct 2007

Morse Robert, Shaw Debra J, Todd Adrian G, Young Philip J

Abstract excerpt

The childhood autosomal recessive disorder spinal muscular atrophy (SMA) is caused by mutations in the survival motor neuron (SMN) gene. SMN localizes diffusely in the cytoplasm and in distinct nuclear structures called Cajal bodies. Cajal bodies are believed to be the storage and processing sites of several ribonucleoproteins. Here, using a novel panel of SMN exon deletion constructs, we report a systematic...

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Identifiers

PMID: 17635841
DOI: 10.1093/hmg/ddm192

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Targeting of SMN to Cajal bodies is mediated by self-association.PMID 17635841Read ↗

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Specific interaction of Smn, the spinal muscular atrophy determining gene product, with hnRNP-R and gry-rbp/hnRNP-Q: a role for Smn in RNA processing in motor axons?Semantic proximity Read ↗

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