Article
[Genotype dependence of cytogenetic and epidemiological characteristics in the liquidators of the accident at the ChNPP].
Radiatsionnaia biologiia, radioecologiia - 1 Jan 2000
Sal'nikova L E, Fomin D K, Elisova T V, Akaeva E A, Kuz'mina N S, Lapteva N Sh, Nilova I N, Iofa E L, Kostina L N, Kuznetsova G I, Kulikova T A, Panushkina O G, Rubanovich A V
Abstract excerpt
The dependence of the level of unstable chromosome aberrations and nononcological diseases on the genotype in 57 liquidators of the ChNPP accident was studied. Candidate genes presumably affecting radiosensitivity were highly polymorphic loci of xenobiotic detoxication genes (glutathione-S-transferases GSTM1, GSTT1, GSTP1) and the 5,10-methylenetetrahydrofolate reductase gene (MTHFR) involved in DNA methylation...
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