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Article

The kinase domain of mitochondrial PINK1 faces the cytoplasm

7 Aug 2008

Abstract excerpt

Mutations in PTEN-induced putative kinase 1 (PINK1) are a cause of autosomal recessive familial Parkinson's disease (PD). Efforts in deducing the PINK1 signaling pathway have been hindered by controversy around its subcellular and submitochondrial localization and the authenticity of its reported substrates. We show here that this mitochondrial protein exhibits a topology in which the kinase domain faces the...

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PMID: 18687899
DOI: 10.1073/pnas.0802814105

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