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Article

Highly multiplexed genotyping of thiopurine s-methyltransferase variants using MALD-TOF mass spectrometry: reliable genotyping in different ethnic groups.

Clinical chemistry - 1 Oct 2008

Schaeffeler Elke, Zanger Ulrich M, Eichelbaum Michel, Asante-Poku Steven, Shin Jae-Gook, Schwab Matthias

Abstract excerpt

BACKGROUND: To avoid severe hematotoxicity in patients, determination of the TPMT (thiopurine S-methyltransferase) genotype before commencing thiopurine therapy has become accepted. METHODS: We used MALDI-TOF mass spectrometry (MS) based on Sequenom iPLEX technology to develop novel multiplex assays for comprehensive testing of TPMT. Two assays, a 15-plex and a 7-plex assay, consisting of multiplex PCR, shrimp...

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Source

Identifiers

PMID: 18687736
DOI: 10.1373/clinchem.2008.103457

Genes

TPMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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