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Gene Expression Analysis of Host Innate Immune Responses during Lethal H5N1 Infection in Ferrets

7 Aug 2008

Abstract excerpt

How viral and host factors contribute to the severe pathogenicity of the H5N1 subtype of avian influenza virus infection in humans is poorly understood. We identified three clusters of differentially expressed innate immune response genes in lungs from H5N1 (A/Vietnam/1203/04) influenza virus-infected ferrets by oligonucleotide microarray analysis. Interferon response genes were more strongly expressed in...

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PMID: 18684821
DOI: 10.1128/jvi.00691-08

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