Host gene expression profiles in ferrets infected with genetically distinct henipavirus strains

Abstract excerpt

Henipavirus infection causes severe respiratory and neurological disease in humans that can be fatal.To characterize the pathogenic mechanisms of henipavirus infection in vivo, we performed experimental infections in ferrets followed by genome-wide gene expression analysis of lung and brain tissues.The Hendra, Nipah-Bangladesh, and Nipah-Malaysia strains caused severe respiratory and neurological disease with...

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