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Article

The cia operon of Streptococcus mutans encodes a unique component required for calcium-mediated autoregulation.

Molecular microbiology - 1 Oct 2008

He Xuesong, Wu Chenggang, Yarbrough Daniel, Sim Lucy, Niu Guoqing, Merritt Justin, Shi Wenyuan, Qi Fengxia

Abstract excerpt

Streptococcus mutans is a primary pathogen for dental caries in humans. CiaR and CiaH of S. mutans comprise a two-component signal transduction system (TCS) involved in regulating various virulent factors. However, the signal that triggers the CiaRH response remains unknown. In this study, we show that calcium is a signal for regulation of the ciaRH operon, and that a double-glycine-containing small peptide...

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Identifiers

PMID: 18681938
DOI: 10.1111/j.1365-2958.2008.06390.x
PMCID: PMC2955730

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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