Article
Suppression of dendritic cell differentiation through cytokines released by Primary Effusion Lymphoma cells.
Immunology letters - 30 Oct 2008
Cirone Mara, Lucania Giuseppe, Aleandri Silvia, Borgia Giuliana, Trivedi Pankaj, Cuomo Laura, Frati Luigi, Faggioni Alberto
Abstract excerpt
Functional impairment of dendritic cells (DC) appears to be one of the mechanisms responsible for tumor escape from the control of the immune system. DC isolated from tumor-bearing animals and cancer patients with solid or with hematological malignancies have phenotypic and functional abnormalities. In addition, supernatants from in vitro cultured tumor cells have been shown to interfere with DC differentiation...
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