Article
Heavily glycosylated, highly fit SIVMne variants continue to diversify and undergo selection after transmission to a new host and they elicit early antibody dependent cellular responses but delayed neutralizing antibody responses.
Virology journal - 4 Aug 2008
Eastman Dawnnica, Piantadosi Anne, Wu Xueling, Forthal Donald N, Landucci Gary, Kimata Jason T, Overbaugh Julie
Abstract excerpt
BACKGROUND: Lentiviruses such as human and simian immunodeficiency viruses (HIV and SIV) undergo continual evolution in the host. Previous studies showed that the late-stage variants of SIV that evolve in one host replicate to significantly higher levels when transmitted to a new host. However, it is unknown whether HIVs or SIVs that have higher replication fitness are more genetically stable upon transmission to...
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