Article
Replicative oncolytic herpes simplex viruses in combination cancer therapies.
Current gene therapy - 1 Mar 2004
Post Dawn E, Fulci Giulia, Chiocca E Antonio, Van Meir Erwin G
Abstract excerpt
Viruses that kill the host cell during their replication cycle have attracted much interest for the specific killing of tumor cells and this oncolytic virotherapy is being evaluated in clinical trials. The rationale for using replicative oncolytic viruses is that viral replication in infected tumor cells will permit in situ viral multiplication and spread of viral infection throughout the tumor mass thus...
Topics
- Chemotherapy, Adjuvant
- Genes, Transgenic, Suicide
- Genetic Therapy
- Genetic Vectors
- Herpesvirus 1, Human
- Humans
- Mutation
- Neoplasms
- Radiotherapy, Adjuvant
- Virus Replication