Article
Interferon-gamma and interleukin-12 gene polymorphisms and their relation to aggressive and chronic periodontitis and key periodontal pathogens.
Journal of periodontology - 1 Aug 2008
Reichert Stefan, Machulla Helmut K G, Klapproth Jana, Zimmermann Uta, Reichert Yvonne, Gläser Christiane, Schaller Hans-Günter, Schulz Susanne
Abstract excerpt
BACKGROUND: The gene polymorphisms interferon-gamma (IFN-gamma) 874 T/A and interleukin (IL)-12 1188 A/C have been associated with the altered production of cytokines. Therefore, they might be indicative of the occurrence of chronic periodontitis (CP) or aggressive periodontitis (AgP) and the prevalence of key periodontal pathogens. For this purpose, we analyzed these polymorphisms in subjects with generalized...
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