Article
Active site mapping of MraY, a member of the polyprenyl-phosphate N-acetylhexosamine 1-phosphate transferase superfamily, catalyzing the first membrane step of peptidoglycan biosynthesis.
Biochemistry - 26 Aug 2008
Al-Dabbagh Bayan, Henry Xavier, El Ghachi Meriem, Auger Geneviève, Blanot Didier, Parquet Claudine, Mengin-Lecreulx Dominique, Bouhss Ahmed
Abstract excerpt
The MraY transferase is an integral membrane protein that catalyzes an essential step of peptidoglycan biosynthesis, namely the transfer of the phospho-N-acetylmuramoyl-pentapeptide motif onto the undecaprenyl phosphate carrier lipid. It belongs to a large superfamily of eukaryotic and prokaryotic prenyl sugar transferases. No 3D structure has been reported for any member of this superfamily, and to date MraY is...
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