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Article

The DNA damage sensors ataxia-telangiectasia mutated kinase and checkpoint kinase 2 are required for hepatitis C virus RNA replication.

Journal of virology - 1 Oct 2008

Ariumi Yasuo, Kuroki Misao, Dansako Hiromichi, Abe Ken-Ichi, Ikeda Masanori, Wakita Takaji, Kato Nobuyuki

Abstract excerpt

Cellular responses to DNA damage are crucial for maintaining genome integrity, virus infection, and preventing the development of cancer. Hepatitis C virus (HCV) infection and the expression of the HCV nonstructural protein NS3 and core protein have been proposed as factors involved in the induction of double-stranded DNA breaks and enhancement of the mutation frequency of cellular genes. Since DNA damage...

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Source

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Identifiers

PMID: 18667510
DOI: 10.1128/JVI.00351-08
PMCID: PMC2546985

Genes

ATM
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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