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Simple multiplex RT‐PCR for identifying common fusion transcripts in childhood acute leukemia

23 Jul 2007

Abstract excerpt

Nonrandom gene rearrangements have been demonstrated in leukemic cells at diagnosis. These genetic abnormalities are associated with specific types, clinical characteristics, and prognosis of acute leukemia. Common fusion transcripts in childhood acute lymphoblastic leukemia (ALL) are TEL-AML1, E2A-PBX, MLL-AF4, and BCR-ABL (p190) and in acute nonlymphoblastic leukemia (ANLL) are AML-ETO, PML-RARA, and...

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PMID: 18665825
DOI: 10.1111/j.1751-553x.2007.00954.x

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