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Article

DNMT3b -149C/T promoter variants and methylation of colorectal cancer-associated genes.

Cancer biomarkers : section A of Disease markers - 1 Jan 2015

Naghibalhossaini Fakhraddin, Mokarram Pooneh, Khalili Eslam, Naghibalhossaini Samaneh

Abstract excerpt

OBJECTIVE: DNMT3B overexpression has been linked with the CpG island methylator phenotype in various cancers. Considering the role of the DNMT3b -149C/T promoter polymorphism on the gene expression, we evaluated the associations of this polymorphism with colorectal cancer (CRC) risk and hypermethylation of six tumor suppressor genes in CRC tumors. METHODS: The DNMT3b was genotyped by PCR-RFLP in 108 sporadic CRC...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 25769449
DOI: 10.3233/CBM-150463
PMCID: PMC12964684

Genes

DNMT3B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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