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Article

Kinetics of omeprazole and escitalopram in relation to the CYP2C19*17 allele in healthy subjects.

European journal of clinical pharmacology - 1 Dec 2008

Ohlsson Rosenborg Staffan, Mwinyi Jessica, Andersson Maria, Baldwin R Michael, Pedersen Rasmus Steen, Sim Sarah C, Bertilsson Leif, Ingelman-Sundberg Magnus, Eliasson Erik

Abstract excerpt

PURPOSE: Ultrarapid drug metabolism of antidepressants has been associated with therapeutic failures. The CYP2C19*17 allele has been associated with higher levels of CYP2C19 gene transcription and increased rates of omeprazole and mephenytoin metabolism. The aim of this study was to compare the impact of the CYP2C19*17 allele on omeprazole single-dose kinetics with escitalopram exposure at steady state in...

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Source

Identifiers

PMID: 18654768
DOI: 10.1007/s00228-008-0529-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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