Article
Absence of H186R polymorphism in exon 4 of the APOBEC3G gene among North Indian individuals.
Genetic testing - 1 Sept 2008
Rathore Anurag, Chatterjee Animesh, Yamamoto Naohiko, Dhole Tapan N
Abstract excerpt
AIDS restriction genes have been defined in which allelic variations have been shown to influence infection or disease progression. Members of the APOBEC family of cellular polynucleotide cytidine deaminases (e.g., APOBEC3G) have been identified as a host factor that inhibits HIV-1 replication. It deaminates cytidine to uridine in nascent minus-strand viral DNA, inducing G-to-A hypermutation in the plus-strand...
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