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Article

A role for fibroblasts in mediating the effects of tobacco-induced epithelial cell growth and invasion.

Molecular cancer research : MCR - 1 Jul 2008

Coppe Jean-Philippe, Boysen Megan, Sun Chung Ho, Wong Brian J F, Kang Mo K, Park No-Hee, Desprez Pierre-Yves, Campisi Judith, Krtolica Ana

Abstract excerpt

Cigarette smoke and smokeless tobacco extracts contain multiple carcinogenic compounds, but little is known about the mechanisms by which tumors develop and progress upon chronic exposure to carcinogens such as those present in tobacco products. Here, we examine the effects of smokeless tobacco extracts on human oral fibroblasts. We show that smokeless tobacco extracts elevated the levels of intracellular...

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Identifiers

PMID: 18644973
DOI: 10.1158/1541-7786.MCR-08-0062
PMCID: PMC2768668

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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