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Article

Significance analysis of spectral count data in label-free shotgun proteomics.

Molecular & cellular proteomics : MCP - 1 Dec 2008

Choi Hyungwon, Fermin Damian, Nesvizhskii Alexey I

Abstract excerpt

Spectral counting has become a commonly used approach for measuring protein abundance in label-free shotgun proteomics. At the same time, the development of data analysis methods has lagged behind. Currently most studies utilizing spectral counts rely on simple data transforms and posthoc corrections of conventional signal-to-noise ratio statistics. However, these adjustments can neither handle the bias toward...

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PMID: 18644780
DOI: 10.1074/mcp.M800203-MCP200
PMCID: PMC2596341

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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