Article
Mutations within the Ddc promoter alter its neuron-specific pattern of expression.
Developmental biology - 1 Aug 1991
Scholnick S B, Caruso P A, Klemencic J, Mastick G S, Mauro C, Rotenberg M
Abstract excerpt
The Drosophila dopa decarboxylase gene (Ddc) is expressed in a reproducible set of approximately 150 neurons, and in a subset of the glia of the third instar larva's central nervous system (CNS). Expression in this pattern requires a cell type-specific neuronal enhancer/glial repressor region located 1000 bp from the transcriptional start site, and specific sequences within the promoter. We have used mutagenesis...
Topics
- Animals
- Animals, Genetically Modified
- Central Nervous System
- Chromosome Deletion
- Dopa Decarboxylase
- Drosophila
- Enhancer Elements, Genetic
- Gene Expression Regulation
- Mutation
- Neurons
- Promoter Regions, Genetic