Article
ORTH/VIM proteins that regulate DNA methylation are functional ubiquitin E3 ligases.
The Plant journal : for cell and molecular biology - 1 Dec 2008
Kraft Edward, Bostick Magnolia, Jacobsen Steven E, Callis Judy
Abstract excerpt
Appropriate methylation of genomes is essential for gene regulation. Here, we describe the six-member ORTHRUS (ORTH) gene family of Arabidopsis thaliana that plays a role in DNA methylation in vivo. ORTH1- ORTH5 are predicted to encode proteins that contain one plant homeodomain (PHD), two really interesting new gene (RING) domains, and one set ring associated (SRA) domain, whereas ORTHlike-1 encodes a protein...
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