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Article

Mutations linked to interstitial lung disease can abrogate anti-amyloid function of prosurfactant protein C.

The Biochemical journal - 1 Dec 2008

Nerelius Charlotte, Martin Emily, Peng Siwei, Gustafsson Magnus, Nordling Kerstin, Weaver Timothy, Johansson Jan

Abstract excerpt

The newly synthesized proSP-C (surfactant protein C precursor) is an integral ER (endoplasmic reticulum) membrane protein with a single metastable polyvaline alpha-helical transmembrane domain that comprises two-thirds of the mature peptide. More than 20 mutations in the ER-lumenal CTC (C-terminal domain of proSP-C), are associated with ILD (interstitial lung disease), and some of the mutations cause...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Source

Identifiers

PMID: 18643778
DOI: 10.1042/BJ20080981

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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