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Article

Nucleophosmin mutation in Southeast Asian acute myeloid leukemia: eight novel variants, FLT3 coexistence and prognostic impact of NPM1/FLT3 mutations.

Haematologica - 1 Oct 2008

Boonthimat Chetsada, Thongnoppakhun Wanna, Auewarakul Chirayu U

Abstract excerpt

NPM1 mutations were investigated in 400 Southeast Asian leukemia patients and were detectable in 105 cases (26.25%) of acute myeloid leukemia but in no cases of acute lymphoid leukemia or chronic myeloid leukemia. Eight novel and 5 known mutations were identified. All predicted novel proteins shared the last five amino acids VSLRK with the similar gain of nuclear exporting signal motif as known variants. Older...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to fms-Like Tyrosine Kinase 3

Share to Leukemia, Myeloid, Acute

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Source

Identifiers

PMID: 18641025
DOI: 10.3324/haematol.12937

Genes

NPM1
FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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