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Polymorphisms in cell cycle regulatory genes, urinary arsenic profile and urothelial carcinoma.

Toxicology and applied pharmacology - 15 Oct 2008

Chung Chi-Jung, Huang Chi-Jung, Pu Yeong-Shiau, Su Chien-Tien, Huang Yung-Kai, Chen Ying-Ting, Hsueh Yu-Mei

Abstract excerpt

INTRODUCTION: Polymorphisms in p53, p21 and CCND1 could regulate the progression of the cell cycle and might increase the susceptibility to inorganic arsenic-related cancer risk. The goal of our study was to evaluate the roles of cell cycle regulatory gene polymorphisms in the carcinogenesis of arsenic-related urothelial carcinoma (UC). METHODS: A hospital-based case-controlled study was conducted to explore the...

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PMID: 18640142
DOI: 10.1016/j.taap.2008.06.011

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