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Polymorphism of inflammatory genes and arsenic methylation capacity are associated with urothelial carcinoma.

Toxicology and applied pharmacology - 1 Oct 2013

Wu Chia-Chang, Huang Yung-Kai, Chung Chi-Jung, Huang Chao-Yuan, Pu Yeong-Shiau, Shiue Horng-Sheng, Lai Li-An, Lin Ying-Chin, Su Chien-Tien, Hsueh Yu-Mei

Abstract excerpt

Chronic exposure to arsenic can generate reactive oxidative species, which can induce certain proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and interleukin-8 (IL-8). TNF-α, IL-6 and IL-8 have been shown to be involved in the development and progression of various cancers, including bladder cancer. This study aimed to investigate the joint effect of the polymorphism of...

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PMID: 23727622
DOI: 10.1016/j.taap.2013.05.019

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