A novel functional polymorphism in the Cdc6 promoter is associated with the risk for hepatocellular carcinoma.

doi:10.1016/j.mrfmmm.2008.06.006

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Article

A novel functional polymorphism in the Cdc6 promoter is associated with the risk for hepatocellular carcinoma.

Mutation research - 25 Aug 2008

Xiong Xing-Dong, Fang Jian-Hong, Qiu Fu-En, Zhao Jing, Cheng Jiasen, Yuan Yunfei, Li Sheng-Ping, Zhuang Shi-Mei

Abstract excerpt

Cdc6 is essential for DNA replication and its deregulation is involved in carcinogenesis. To date, the biological significance of the polymorphism in Cdc6 promoter is still unknown. In this study, we aimed to evaluate the influence of the Cdc6 -515A>G polymorphism (rs4134994) on the individual's susceptibility to cancer and on the function of Cdc6. The Cdc6 -515A>G polymorphism was genotyped in 387 hepatocellular...

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PMID: 18640135
DOI: 10.1016/j.mrfmmm.2008.06.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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