Molecular and cytogenetic characterization of a novel translocation t(4;22) involving the breakpoint cluster region and platelet‐derived growth factor receptor–alpha genes in a patient with atypical chronic myeloid leukemia

Abstract excerpt

We report a case of BCR-ABL-negative atypical chronic myeloid leukemia (CML) with translocation t(4;22) (q12;q11.2) juxtaposing the breakpoint cluster region (BCR) and platelet-derived growth factor receptor-alpha (PDGFRA) genes. The patient was a 57-year-old man with a history of stage IV diffuse large B-cell lymphoma, status post-6 cycles of combination chemotherapy in 1999, who presented in August 2002 with...

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