Article
Three single nucleotide polymorphisms leading to non-synonymous amino acid substitution in the human ribonuclease 2 and angiogenin genes exhibit markedly less genetic heterogeneity in six populations.
Cell biochemistry and function - 1 Aug 2008
Ueki Misuzu, Takeshita Haruo, Fujihara Junko, Takatsuka Hisakazu, Yuasa Isao, Iida Reiko, Yasuda Toshihiro
Abstract excerpt
Angiogenin and ribonuclease 2 (RNase 2) are members of the human RNase superfamily. Although three potential single nucleotide polymorphisms (SNPs) in these genes, which could give rise to an amino acid substitution in the protein, have been identified, relevant population data are not available, and accordingly they have not been applied to clinical-genetic analysis. For this purpose, a novel genotyping method...
Topics
- Amino Acid Substitution
- Asian People
- Black People
- Endoribonucleases
- Gene Frequency
- Genetics, Population
- Genotype
- Humans
- Polymorphism, Single Nucleotide
- Ribonuclease, Pancreatic
- White People