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Host-derived oxidized phospholipids and HDL regulate innate immunity in human leprosy

30 Jul 2008

Abstract excerpt

Intracellular pathogens survive by evading the host immune system and accessing host metabolic pathways to obtain nutrients for their growth. Mycobacterium leprae, the causative agent of leprosy, is thought to be the mycobacterium most dependent on host metabolic pathways, including host-derived lipids. Although fatty acids and phospholipids accumulate in the lesions of individuals with the lepromatous (also...

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PMID: 18636118
DOI: 10.1172/jci34189

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