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Article

The identification and characterization of a FOXL2 response element provides insights into the pathogenesis of mutant alleles.

Human molecular genetics - 15 Oct 2008

Benayoun Bérénice A, Caburet Sandrine, Dipietromaria Aurélie, Bailly-Bechet Marc, Batista Frank, Fellous Marc, Vaiman Daniel, Veitia Reiner A

Abstract excerpt

The Forkhead transcription factor FOXL2 plays a crucial role in ovarian development and maintenance. In humans, its mutations lead to craniofacial abnormalities, isolated or associated with ovarian dysfunction. Using a combinatorial approach, we identified and characterized a FoxL2 response element (FLRE) and showed that it is highly specific and that it diverges from that of other Forkhead transcription factors....

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Source

Identifiers

PMID: 18635577
DOI: 10.1093/hmg/ddn209

Genes

FOXL2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The identification and characterization of a FOXL2 response element provides insights into the pathogenesis of mutant alleles.PMID 18635577Read ↗

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<i>FOXL2 </i>Impairment in Human DiseaseSemantic proximity Read ↗

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