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Article

Structure, evolution and expression of the FOXL2 transcription unit

1 Jan 2003

Abstract excerpt

FOXL2 is a putative transcription factor involved in ovarian development and function. Its mutations in humans are responsible for the blepharophimosis syndrome, characterized by eyelid malformations and premature ovarian failure (POF). Here we have performed a comparative sequence analysis of FOXL2 sequences of ten vertebrate species. We demonstrate that the entire open reading frame (ORF) is under purifying...

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PMID: 14684984
DOI: 10.1159/000074338

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