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Article

Analysis of Venezuelan equine encephalitis replicon particles packaged in different coats.

PloS one - 16 Jul 2008

Kamrud Kurt I, Alterson Kim D, Andrews Chasity, Copp Laura O, Lewis Whitney C, Hubby Bolyn, Patel Deepa, Rayner Jonathan O, Talarico Todd, Smith Jonathan F

Abstract excerpt

BACKGROUND: The Venezuelan equine encephalitis (VEE) virus replicon system was used to produce virus-like replicon particles (VRP) packaged with a number of different VEE-derived glycoprotein (GP) coats. The GP coat is believed to be responsible for the cellular tropism noted for VRP and it is possible that different VEE GP coats may have different affinities for cells. We examined VRP packaged in four different...

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PMID: 18628938
DOI: 10.1371/journal.pone.0002709
PMCID: PMC2447172

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