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Article

Transforming Growth Factor-βs and Their Signaling Receptors Are Coexpressed in Crohn's Disease

1 Jan 1999

Abstract excerpt

OBJECTIVE: To evaluate mechanisms that contribute to tissue repair and tissue remodeling in Crohn's disease (CD). SUMMARY BACKGROUND DATA: Transforming growth factor-betas (TGF-betas) are involved in different chronic inflammatory disorders. They function by binding to two receptors, type I (TbetaR-I) subtype ALK5 and type II (TbetaR-II), which are concomitantly required for signal transduction. METHODS: Tissues...

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PMID: 9923802
DOI: 10.1097/00000658-199901000-00009

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