Article
Fluid shear stress magnitude, duration, and total applied load regulate gene expression and nitric oxide production in primary calvarial osteoblast cultures.
Plastic and reconstructive surgery - 1 Aug 2008
González Octavio, Fong Kenton D, Trindade Michael C D, Warren Stephen M, Longaker Michael T, Smith R Lane
Abstract excerpt
BACKGROUND: Successful bone engineering requires an understanding of the effects of mechanical stress on osteoblast differentiation. Therefore, we examined the effects of varying magnitude and duration of fluid shear stress on factors associated with osteoblastic differentiation. METHODS: Using a cone viscometer, primary neonatal rat calvarial osteoblasts were exposed to continuous fluid shear stress at varying...
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