Article
CUL-2 is required for the G1-to-S-phase transition and mitotic chromosome condensation in Caenorhabditis elegans.
Nature cell biology - 1 Dec 1999
Feng H, Zhong W, Punkosdy G, Gu S, Zhou L, Seabolt E K, Kipreos E T
Abstract excerpt
The human cullin protein CUL-2 functions in a ubiquitin-ligase complex with the von Hippel-Lindau (VHL) tumour suppressor protein. Here we show that, in Caenorhabditis elegans, cul-2 is expressed in proliferating cells and is required at two distinct points in the cell cycle, the G1-to-S-phase tr...
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