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Article

Contribution of Multiple Inherited Variants to Autism Spectrum Disorder (ASD) in a Family with 3 Affected Siblings.

Genes - 8 Jul 2021

Dhaliwal Jasleen, Qiao Ying, Calli Kristina, Martell Sally, Race Simone, Chijiwa Chieko, Glodjo Armansa, Jones Steven, Rajcan-Separovic Evica, Scherer Stephen W, Lewis Suzanne

Abstract excerpt

Autism Spectrum Disorder (ASD) is the most common neurodevelopmental disorder in children and shows high heritability. However, how inherited variants contribute to ASD in multiplex families remains unclear. Using whole-genome sequencing (WGS) in a family with three affected children, we identified multiple inherited DNA variants in ASD-associated genes and pathways (RELN, SHANK2, DLG1, SCN10A, KMT2C and ASH1L)....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34356069
DOI: 10.3390/genes12071053
PMCID: PMC8303619

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