Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ten recently identified associations between nsSNPs and colorectal cancer could not be replicated in German families.

Cancer letters - 18 Nov 2008

Frank Bernd, Burwinkel Barbara, Bermejo Justo Lorenzo, Försti Asta, Hemminki Kari, Houlston Richard, Mangold Elisabeth, Rahner Nils, Friedl Waltraut, Friedrichs Nicolaus, Buettner Reinhard, Engel Christoph, Loeffler Markus, Holinski-Feder Elke, Morak Monika, Keller Gisela, Schackert Hans K, Krüger Stefan, Goecke Timm, Moeslein Gabriela, Kloor Matthias, Gebert Johannes, Kunstmann Erdmute, Schulmann Karsten, Rüschoff Josef, Propping Peter

Abstract excerpt

Ten non-synonymous single nucleotide polymorphisms (nsSNPs), which were recently associated with colorectal cancer risk in a comprehensive, array based study (AKAP9 M463I, DKK3 G335R, AMPD1 Q12X, LIPC L356F, PSMB9 V32I, THBS1 N700S, CA6 S90G, ASCC3 C1995S, DHX36 S416C and CPA4 G303C) were re-evaluated in the present study based on 626 German familial non-HNPCC colorectal cancer patients and 736 healthy controls....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aged, 80 and over

Share to Case-Control Studies

Share to Colorectal Neoplasms

Share to Germany

Share to Reproducibility of Results

Source

Identifiers

PMID: 18619730
DOI: 10.1016/j.canlet.2008.05.043

Genes

AKAP9
AMPD1
ASCC3
CPA4
DHX36
DKK3
LIPC
PSMB9
THBS1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ten recently identified associations between nsSNPs and colorectal cancer could not be replicated in German families.PMID 18619730Read ↗

Whole-exome sequencing identifies rare pathogenic variants in new predisposition genes for familial colorectal cancer.Semantic proximity Read ↗

IDENTIFICATION OF CLINICALLY RELEVANT GENE VARIANTS IN COLON ADENOCARCINOMA SAMPLES OF UKRAINIAN PATIENTS USING A COMPREHENSIVE CANCER PANEL: A PILOT STUDY.Semantic proximity Read ↗

Search for low penetrance alleles for colorectal cancer through a scan of 1467 non-synonymous SNPs in 2575 cases and 2707 controls with validation by kin-cohort analysis of 14 704 first-degree relatives.Semantic proximity Read ↗

Eleven candidate susceptibility genes for common familial colorectal cancer.Semantic proximity Read ↗

Systematic search for rare variants in Finnish early-onset colorectal cancer patients.Semantic proximity Read ↗

Colorectal cancer risk and patients' survival: influence of polymorphisms in genes somatically mutated in colorectal tumors.Semantic proximity Read ↗

Whole Exome Sequencing Identifies APCDD1 and HDAC5 Genes as Potentially Cancer Predisposing in Familial Colorectal CancerSemantic proximity Read ↗

Exome sequencing in one family with gastric- and rectal cancer.Semantic proximity Read ↗

Recurrent, low-frequency coding variants contributing to colorectal cancer in the Swedish population.Semantic proximity Read ↗

Identification of Novel Loci and New Risk Variant in Known Loci for Colorectal Cancer Risk in East Asians.Semantic proximity Read ↗

Whole Exome Sequencing Identifies APCDD1 and HDAC5 Genes as Potentially Cancer Predisposing in Familial Colorectal Cancer.Semantic proximity Read ↗

Germline Genetic Variants in the Wnt/β-Catenin Pathway as Predictors of Colorectal Cancer Risk.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.