Article
An endophenotype approach to the genetics of alcohol dependence: a genome wide association study of fast beta EEG in families of African ancestry.
Molecular psychiatry - 1 Dec 2017
Meyers J L, Zhang J, Wang J C, Su J, Kuo S I, Kapoor M, Wetherill L, Bertelsen S, Lai D, Salvatore J E, Kamarajan C, Chorlian D, Agrawal A, Almasy L, Bauer L, Bucholz K K, Chan G, Hesselbrock V, Koganti L, Kramer J, Kuperman S, Manz N, Pandey A, Seay M, Scott D, Taylor R E, Dick D M, Edenberg H J, Goate A, Foroud T, Porjesz B
Abstract excerpt
Fast beta (20-28 Hz) electroencephalogram (EEG) oscillatory activity may be a useful endophenotype for studying the genetics of disorders characterized by neural hyperexcitability, including substance use disorders (SUDs). However, the genetic underpinnings of fast beta EEG have not previously been studied in a population of African-American ancestry (AA). In a sample of 2382 AA individuals from 482 families...
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