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Article

Opposing effects of podocin on the gating of podocyte TRPC6 channels evoked by membrane stretch or diacylglycerol.

American journal of physiology. Cell physiology - 1 Aug 2013

Anderson Marc, Kim Eun Young, Hagmann Henning, Benzing Thomas, Dryer Stuart E

Abstract excerpt

Gain-of-function mutations in the transient receptor potential (TRP) cation channel subfamily C member 6 (TRPC6) gene and mutations in the NPHS2 gene encoding podocin result in nephrotic syndromes. The purpose of this study was to determine the functional significance of biochemical interactions between these proteins. We observed that gating of TRPC6 channels in podocytes is markedly mechanosensitive and can be...

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Source

Identifiers

PMID: 23657570
DOI: 10.1152/ajpcell.00095.2013

Genes

TRPC6
ANG
NPHS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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