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Identifying Secondary Mutations in Chinese Patients with Imatinib-Resistant Gastrointestinal Stromal Tumors (GISTs) by Next Generation Sequencing (NGS).

Pathology oncology research : POR - 1 Jan 2020

Du Jiang, Wang Si, Wang Rui, Wang Si-Yao, Han Qiang, Xu Hong-Tao, Yang Peng, Liu Yang

Abstract excerpt

The aim of this study was to characterize secondary kinase mutations in Chinese patients with imatinib-resistant gastrointestinal stromal tumors (GISTs). Mutations in receptor tyrosine kinase (KIT; exons 9, 11, 13, 14, 17, and 18) and platelet-derived growth factor-alpha (PDGFRA; exons 12, 14, and 18) were analyzed by direct sequencing. After imatinib treatment, 425 cancer-related target genes were analyzed by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 31758409
DOI: 10.1007/s12253-019-00770-6

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