Article
Somatic mutations to CSMD1 in colorectal adenocarcinomas.
Cancer biology & therapy - 1 Apr 2008
Farrell Christopher, Crimm Hampton, Meeh Paul, Croshaw Randal, Barbar Thomas, Vandersteenhoven Jacob J, Butler William, Buckhaults Phillip
Abstract excerpt
The short arm of chromosome 8 is frequently deleted in advanced human colorectal cancers, suggesting the presence of one or more tumor suppressor genes having a major role in tumor progression and metastasis. Comprehensive sequencing of over 18,000 genes in colon and breast cancers identified somatic mutations in CUB and Sushi Multiple Domains 1 Gene (CSMD1)which is located on the p arm of chromosome 8. In this...
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