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Article

Two distinct tumor phenotypes isolated from glioblastomas show different MRS characteristics.

NMR in biomedicine - 1 Oct 2008

Thorsen Frits, Jirak Daniel, Wang Jian, Sykova Eva, Bjerkvig Rolf, Enger Per Øyvind, van der Kogel Albert, Hajek Milan

Abstract excerpt

We have developed a human brain tumor model in immunodeficient rats that gradually changes its phenotype by serial passages in vivo, from a highly infiltrative, non-angiogenic one with numerous stem cell markers [low-generation (LG) tumor] to a more typical glioblastoma one with extensive angiogenesis and necrosis [high-generation (HG) tumor]. In this study we determined the metabolic properties of these two...

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PMID: 18613001
DOI: 10.1002/nbm.1263

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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