Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prenatal activation of microglia induces delayed impairment of glutamatergic synaptic function.

PloS one - 9 Jul 2008

Roumier Anne, Pascual Olivier, Béchade Catherine, Wakselman Shirley, Poncer Jean-Christophe, Réal Eleonore, Triller Antoine, Bessis Alain

Abstract excerpt

BACKGROUND: Epidemiological studies have linked maternal infection during pregnancy to later development of neuropsychiatric disorders in the offspring. In mice, experimental inflammation during embryonic development impairs behavioral and cognitive performances in adulthood. Synaptic dysfunctions may be at the origin of cognitive impairments, however the link between prenatal inflammation and synaptic defects...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Embryo, Mammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glutamic Acid

Share to Hippocampus

Share to Microglia

Share to Receptors, AMPA

Share to Synapses

Share to Synaptic Transmission

Source

Open in PubMed Open full text

Identifiers

PMID: 18612411
DOI: 10.1371/journal.pone.0002595
PMCID: PMC2440505

Genes

NOS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prenatal activation of microglia induces delayed impairment of glutamatergic synaptic function.PMID 18612411Read ↗

Impaired synaptic function in the microglial KARAP/DAP12-deficient mouse.Semantic proximity Read ↗

Physiological roles of embryonic microglia and their perturbation by maternal inflammationSemantic proximity Read ↗

At the crux of maternal immune activation: Viruses, microglia, microbes, and <scp>IL‐17A</scp>Semantic proximity Read ↗

Maternal Immune Activation Alters Temporal Precision of Spike Generation of CA1 Pyramidal Neurons by Unbalancing GABAergic Inhibition in the OffspringSemantic proximity Read ↗

Interaction between maternal immune activation and postpartum immune stress in neuropsychiatric phenotypes.Semantic proximity Read ↗

Prenatal inflammation and neurodevelopment in schizophrenia: A review of human studiesSemantic proximity Read ↗

Reversing behavioural abnormalities in mice exposed to maternal inflammation.Semantic proximity Read ↗

Ikzf1 as a novel regulator of microglial homeostasis in inflammation and neurodegenerationSemantic proximity Read ↗

Maternal Immune Activation Induces Neuroinflammation and Cortical Synaptic Deficits in the Adolescent Rat Offspring.Semantic proximity Read ↗

Early-childhood inflammation blunts the transcriptional maturation of cerebellar neuronsSemantic proximity Read ↗

A unique cerebellar pattern of microglia activation in a mouse model of encephalopathy of prematuritySemantic proximity Read ↗

Modulating microglia activation prevents maternal immune activation induced schizophrenia-relevant behavior phenotypes via arginase 1 in the dentate gyrus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.