Article
VSV-G pseudotyping rescues HIV-1 CA mutations that impair core assembly or stability.
Retrovirology - 7 Jul 2008
Brun Sonia, Solignat Maxime, Gay Bernard, Bernard Eric, Chaloin Laurent, Fenard David, Devaux Christian, Chazal Nathalie, Briant Laurence
Abstract excerpt
BACKGROUND: The machinery of early HIV-1 replication still remains to be elucidated. Recently the viral core was reported to persist in the infected cell cytoplasm as an assembled particle, giving rise to the reverse transcription complex responsible for the synthesis of proviral DNA and its transport to the nucleus. Numerous studies have demonstrated that reverse transcription of the HIV-1 genome into proviral...
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