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Article

Inactive S298R disassembles the dodecameric L-aspartate 4-decarboxylase into dimers.

Biochemical and biophysical research communications - 12 Sept 2008

Wang Nai-Chen, Ko Tzu-Ping, Lee Chia-Yin

Abstract excerpt

L-Aspartate 4-decarboxylase catalyzes the conversion of aspartate to alanine and CO(2). The wild-type enzyme was observed as dodecamers at pH 5.0. The mutation of Ser298 into Arg resulted in an almost complete loss of the enzyme activity, and caused regional structural distortion and defects in the enzyme assembly, as shown in circular dichroism spectra and gel filtration profiles. Mutating Tyr207 and Pro257 into...

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PMID: 18602363
DOI: 10.1016/j.bbrc.2008.06.110

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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