Article
Pharmacokinetics of 5-fluorouracil in patients heterozygous for the IVS14+1G > A mutation in the dihydropyrimidine dehydrogenase gene.
Nucleosides, nucleotides & nucleic acids - 1 Jun 2008
van Kuilenburg A B P, Maring J G, Schalhorn A, Terborg C, Schmalenberg H, Behnke D, Schwabe W, Jabschinsky K, Hausler P
Abstract excerpt
5-Fluorouracil (5FU) and capecitabine are two of the most frequently prescribed chemotherapeutic drugs for the treatment of patients with cancer. Administration of test doses of 5FU to eight patients heterozygous for the IVS14+1G > A mutation and five control patients showed that the AUC and clearance were weak parameters with respect to the identification of patients with a DPD deficiency. However, highly...
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